The first anti-cancer study using purified CYN was carried out by Fischell et al. (1995). They reported growth-inhibitory effects of CYN against eight cancer cell lines of human origin. Barbier et al. (2001) reported on the anti-proliferative activity of CYN on the tumour cell line SK-N-SH. They observed a loss of neuritis and a compaction of the microtubule network in response to low doses of CYN. IC50 values of CYN were similar to those of the well-established anti-cancer drug cisplatinum.
Anti-proliferative and apoptotic effects of both purified CYN and meth-anolic extracts of C. racemosa on the chemosensitive SH-SY-5Y and chemoresistant Kelly cell lines were reported by Cavas et al. (2006). IC50 values were obtained for SHSY5Y and Kelly cell lines as 0.59 ± 0.06, 1.06 ± 0.23 g wet weight alga/mL methanol and 5.64 ± 0.09, 6.02 ± 0.09 mM CYN, respectively.
Cytotoxic effect of a crude acetone extract of C. racemosa on a human melanoma cancer cell line was reported by Rocha et al. (2007). Ji et al. (2008) isolated polysaccharides from C. racemosa and showed their anti-tumour activity both in vivo and in vitro on K562 cells.
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