Brucella abortus virB operon

The complete virB operon coding for a number of proteins that form a type IV secretion system is present in B. abortus. In A. tumefaciens virB operon is involved in the conjugation of the T-DNA from bacteria to plant cell. B. abortus virB null mutants are avirulent in mice and do not multiply inside HeLa or macrophage cells. The mutants are unable to prevent the fusion between the early endosome with the lysosome and, as a consequence, they do not reach the endoplasmic reticulum to establish their intracellular multiplication niche.

Section 13: Nitrification, Denitrification and the Nitrogen Cycle

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