Compared to anaerobic granules, aerobic granules have relatively low stability. It would be desirable to develop a practical strategy for improving the stability of aerobic granules by manipulating operational conditions or through selecting for slow-growth bacteria. The mechanisms and rates of cell attachment-detachment in the granule are not known clearly. The life cycle of the granules was not studied and it is not clear whether new granules are faster produced from the existing granules, from cells, or particles of disrupted granules.
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