Physiological Diversity in Aerobic Microbial Granules

The important aspect of granulation is physiological diversity of microbial cells in the granule. For example, distribution of cells by phases of cells division cycle or mytotic cycle can produce significant information about cell activity and interactions inside the granule. It was not studied yet, the coordination between biochemical and physiological cell activities such as individual RNAs and enzymes synthesis and degradation, regulation of enzyme activity by metabolites and cofactors, regulation of catabolism and energy storage, regulation of whole-cell activity by different cell regulators during granule formation and maturation.

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