Mechanisms of Aerobic Granulation

Although extensive work has been done in the area of aerobic granulation, future research needs to look into different aspects of physiology, ecology, and molecular biology of microbial granules. Further research needs to address a basic question about formation mechanisms of anaerobic and aerobic granules. It is clear that different physico-chemical mechanisms, such as hydrophobic and electrostatic cell-cell interactions, formation of polysaccharide matrix and salt bridges connecting cells, biologically specific cell-to-cell aggregation, formation of mechanically strong outer frame ("skin") and inner frame of filamentous bacteria are important in granulation but the specificity and role of these mechanisms have not been studied yet.

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